ABSTRACT
Objective To investigate the clinical efficacy of hydrocortisone sodium succinate for treatment of septic shock patients and their prognoses. Methods A prospective case control study was conducted. 49 patients with septic shock in the Department of Emergency of the First Affiliated Hospital of Xi'an Jiaotong University were enrolled from January 2010 to January 2012,and the patients were sequentially divided into two groups,the treatment group(24 cases)and the control group(25 cases),by the difference in odd or even number. All patients in the two groups accepted the conventional treatment. The treatment group additionally received hydrocortisone sodium succinate injection 200 mg,once a day for 5 days. The levels of serum procalcitonin(PCT),C-reactive protein(CRP)were measured in all the patients before treatment and 24 hours,72 hours and 7 days after treatment. The mortalities were compared in 14 days between the two groups. Results The levels of PCT,CRP before and 24 hours after treatment were not statistically significant different from those of pre-treatment in two groups(all P>0.05). PCT and CRP were decreased at 72 hours and 7 days after treatment in the two groups,and on the 7th day the decline was more significant, and compared with the control group,the levels of PCT and CRP in treatment group were reduced more markedly at 72 hours and on the 7th day〔PCT(μg/L):72 hours 9.73±2.10 vs. 12.36±2.56,7 days 5.33±2.05 vs. 8.76±1.78;CRP(μg/L):72 hours 69.12±13.61 vs. 109.68±16.16,7 days 20.16±9.64 vs. 42.32±13.16,all P0.05). Conclusion The treatment with hydrocortisone sodium succinate can reduce the inflammation of patients with septic shock,thus it has clinical value in the improvement of the disease situation.
ABSTRACT
Objective To explore the effect of hydrocortisone sodium succinate on perioperative airway management in bronchial asthma patients. Methods 47 perioperative bronchial asthma patients with artificial airway in Linzhou City People Hospital were enrolled,and they were randomly divided into control group(24 cases) and therapy group(23 cases). Doxofylline 300 mg intravenous(IV)drip per day was given to the patients in both groups,and in therapy group,additionally hydrocortisone sodium succinate 500 mg IV drip per day was applied. The remission of asthma and changes in vital signs,arterial blood gas and respiratory function were observed in both groups. Results There were no significant differences in remission rate and invalid number at 30 minutes after treatment between therapy group and control group(both P>0.05). The remission rate of asthma in therapy group at 1 hour after treatment was significantly higher than that in control group(95.7%vs. 66.7%,P=0.023),the mean remission time was shorter than that in control group(minutes:38.09±15.93 vs. 45.83±18.75,P=0.012),the respiratory rate was lower(beats/min:20.8±2.3 vs. 22.3±3.3,P=0.042),and arterial partial pressure of oxygen〔PaO2(mmHg,1 mmHg=0.133 kPa):83.5±8.9 vs. 77.9±7.4,P=0.028〕,lactate〔Lac(mmol/L):1.87±0.29 vs. 2.09±0.33,P=0.029〕,forced vital capacity〔FVC(L):3.84±0.23 vs. 3.65±0.31,P=0.004〕and forced expiratory volume in 1 second〔FEV1(L):3.34±0.20 vs. 3.16±0.29,P=0.003〕were significantly increased compared with those in control group. But there were no significant differences in heart rate(HR),arterial oxygen saturation(SaO2),pH value,arterial partial pressure of carbon dioxide(PaCO2),FEV1/FVC,and peak expiratory flow (PEF)between the two groups(all P>0.05). Conclusion Hydrocortisone sodium succinate in conjunction with doxofylline can relax the symptom of perioperative bronchial asthma patients with artificial airway faster.
ABSTRACT
Steroids constitute a particular class of lipids characterized by a typical tetracyclic skeleton, composed of one five-member ring and three fused six-member rings. Steroids are widely used as therapeutic agents .The present work is on corticosteroid. The corticosteroid used in present research work was 11-β,17-α,21-trihydroxy-4-pregnene-3, 20-dione,21-O-succinate (Hydrocortisone sodium succinate). An attempt was made to cleave the side chain of the precursor corticosteroid by actively growing culture of Pseudomonas putida MTCC 1259. Growing cells of Pseudomonas putida MTCC 1259 were found to effectively convert hydrocortisone succinate in nutrient broth, at pH 7.5, temperature 37 °C when 0.25 to 0.50 mg l-1 substrate was added after 24 hr of inoculation. Higher substrate concentration was found to be inhibitory for the bioconversion of the precursor steroid.